The Evolution of Aesthetic Enhancement

Posted on Wednesday 3rdJanuary 2024

A Review of PDO Threads in Medical Aesthetics by Dr Antonios Petrou-Amerikanos

Dr Antonios Petrou-Amerikanos

In recent years, the demand for non-invasive and minimally-invasive aesthetic procedures has experienced a remarkable surge. Patients are seeking alternatives to surgical interventions that offer effective and natural-looking results with minimal downtime. Among the various options available, Polydioxanone (PDO) threads have emerged as a promising solution.

The Science of PDO Threads

PDO threads are biodegradable sutures made from polydioxanone, a synthetic, absorbable polymer. They have a proven safety profile in various medical applications e.g. resorbable sutures used in surgical procedures, but also in facial aesthetics, for strengthening and supporting the skin as well as repositioning it to achieve lifting. The threads are inserted subcutaneously to lift and tighten sagging skin, stimulate collagen production, and improve overall skin texture. The biocompatible nature of PDO makes it an ideal material for such procedures.

Alternative Thread Materials

In addition to PDO, various alternative materials are used in thread procedures. These materials include Poly-L-Lactic Acid (PLLA), Polycaprolactone (PCL), barbed threads, and threads with hyaluronic acid (HA) coating. Each material possesses unique properties, offering practitioners a range of options for non-surgical facial rejuvenation.

Mechanism of Action

The mechanism of action of PDO threads involves two main processes: mechanical lifting and collagen stimulation.1 The threads provide an immediate lifting effect by physically supporting sagging tissues. Additionally, they stimulate the body’s natural collagen by subclinical inflammation by macrophages, followed by microparticle encapsulation and collagen production by fibroblasts, contributing to long-term improvements in skin elasticity and firmness.2

Applications in non-surgical Facial Rejuvenation

PDO threads have shown remarkable efficacy in addressing various aesthetic concerns, including facial sagging, fine lines, and wrinkles. Common applications include:

• Mid-facial rejuvenation: PDO threads can lift and tighten the mid-face, reducing the appearance of nasolabial folds and marionette lines.

• Neck and jawline contouring: The threads are used to redefine the jawline and improve the contour of the neck, providing a more youthful appearance.

• Eyebrow and eyelid lift: PDO threads offer a non-surgical alternative to lift and rejuvenate the eyebrows and eyelids, reducing hooding and restoring a refreshed look.

• Collagen boosting: Beyond immediate lifting effects, PDO threads stimulate collagen synthesis, promoting natural rejuvenation over time.

Read the full article by Dr Antonios Petrou-Amerikanos in Aesthetic Medicine Magazine